The Genetics of Dilated Cardiomyopathy: A Prioritized Candidate Gene Study ofLMNA,TNNT2,TCAP, andPLN
نویسندگان
چکیده
منابع مشابه
Genetics and dilated cardiomyopathy: limitations of candidate gene strategies.
What is known of the genetic basis for dilated cardiomyopathy is the result of studying pedigrees with intermediate phenotypes. In these diseases the dilated hypocontractile heart is only one feature of the phenotype and other clinical manifestations allow precise definition of affection status. The first such phenotypes to be studied were Duchenne and Becker muscular dystrophies, allelic X-lin...
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ilated cardiomyopathy (DCM), characterized by left venricular dilation and systolic dysfunction, is the most comon form of heart muscle disease, comprising 60% of the ases of identified cardiomyopathies (1). The disorder is linically heterogeneous, ranging from affected individuals ith clinical presentations of severe symptoms, including eart failure, sudden death, or resuscitated sudden death,...
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Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by ventricular dilatation and impaired systolic function, and is a major cause of severe heart failure. Although familial occurrence of DCM has been reported occasionally, the frequency of familial aetiology has been underestimated in the past. Systematic examination of relatives show that probably > 25–30% of DCM cases are fa...
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Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progressio...
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The cardiac troponin complex, which is an important component of the contractile apparatus, is composed of the three subunits troponin I (TnI), troponin C (TnC) and troponin T (TnT). Troponin I is the inhibitory subunit and consists of three isoforms encoded by TNNI1, TNNI2 and TNNI3 genes, respectively. Due to the different types of cardiomyopathies caused by mutations in the TNNI3 gene and it...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 2013
ISSN: 0160-9289
DOI: 10.1002/clc.22193